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Test Directory » LP-PLA2 Activity

LP-PLA2 Activity

Order Code: LPPLA2

Test Summary

Lipoprotein-associated phospholipase A2 (Lp-PLA2), also known as platelet activating factor Acetylhydrolase, is an inflammatory enzyme that circulates bound mainly to low density lipoproteins and has been found to be localized and enriched in atherosclerotic plaques. In multiple clinical trials, Lp-PLA2 activity has been shown to be an independent predictor of coronary heart disease and stroke in the general population. Measurement of Lp-PLA2 may be used along with traditional cardiovascular risk factor measures for identifying individuals at higher risk of cardiovascular disease events. Clinical management may include beginning or intensifying risk reduction strategies. The activity assay is an enzyme assay run on an automated chemistry platform.

Aliases

  • N/A

Specimen Collection

Special Instructions

N/A

Preferred Specimen

1 mL serum collected in a red-top tube (no gel)

Minimum Volume

0.5 mL

Instructions

Recommend to centrifuge and separate samples within four hours of venipuncture as per good laboratory practices.

Patient Preparation

Fasting preferred, but not required

Storage

N/A

Transport Temperature

Refrigerated

Specimen Stability

  • Room temperature: 28 days
  • Refrigerated: 28 days
  • Frozen -20° C: 43 days, Frozen -70° C: 90 days

Limitations

N/A

Other Acceptable Specimens

N/A

Unacceptable Specimens

Hemolysis • Moderate to grossly lipemic • Moderate to grossly icteric

Order Code

LPPLA2

EPIC (Premier) Code

N/A

Includes

N/A

CPT Code

  • 83698

Billing Code

  • 671107

CPT Statement

CPT Statement

Methodology

Enzymatic Assay (EZA)

FDA Status

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Physician Attestation of Informed Consent

N/A

Testing Laboratory

Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675

Department

Reference Testing

Reference Range

≤123 nmol/min/Ml

Setup Schedule / Expected Turnaround Time

Monday - Saturday; Report available: 2 - 3 days

Specimen Collection

Special Instructions

N/A

Preferred Specimen

1 mL serum collected in a red-top tube (no gel)

Minimum Volume

0.5 mL

Instructions

Recommend to centrifuge and separate samples within four hours of venipuncture as per good laboratory practices.

Patient Preparation

Fasting preferred, but not required

Storage

N/A

Transport Temperature

Refrigerated

Specimen Stability

  • Room temperature: 28 days
  • Refrigerated: 28 days
  • Frozen -20° C: 43 days, Frozen -70° C: 90 days

Limitations

N/A

Other Acceptable Specimens

N/A

Unacceptable Specimens

Hemolysis • Moderate to grossly lipemic • Moderate to grossly icteric

Billing

CPT Code

  • 83698

Billing Code

  • 671107

CPT Statement

CPT Statement

Result Information

Methodology

Enzymatic Assay (EZA)

Testing Laboratory

N/A

Reference Range

≤123 nmol/min/Ml

Setup Schedule / Expected Turnaround Time

Monday - Saturday; Report available: 2 - 3 days