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Test Directory » IGF-1, LC/MS

IGF-1, LC/MS

Order Code: IGF1

Test Summary

Insulin-like Growth Factor 1 (IGF-1, or Somatomedin C), a protein involved in stimulating somatic growth, is regulated principally by Growth Hormone (GH) and nutritional intake. IGF-1 is transported in serum by several proteins; this helps maintain relatively high IGF-1 plasma levels and minimizes fluctuations in serum IGF-1 concentrations.
Measuring IGF-1 is useful in several growth-related disorders. Dwarfism caused by deficiency of growth hormone (Hypopituitarism) results in decreased serum levels of IGF-1, while acromegaly (growth hormone excess) results in elevated levels of IGF-1. IGF-1 measurements are also helpful in assessing nutritional status; levels are reduced in undernutrition and restored with a proper diet

Aliases

  • Insulin-Like Growth Factor
  • Insulin Like Growth Factor
  • Somatomedin-C

Specimen Collection

Special Instructions

N/A

Preferred Specimen

0.5 mL serum

Minimum Volume

0.3 mL

Instructions

Collect blood in a red-top or SST vacutainer. For red-top vacutainers, allow blood to clot (10-15 minutes) at room temperature. Separate serum from cells and refrigerate.

Patient Preparation

N/A

Storage

Plastic screw-cap vial

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

  • Room temperature: 48 hours
  • Refrigerated: 7 days
  • Frozen: 60 days

Limitations

N/A

Other Acceptable Specimens

N/A

Unacceptable Specimens

Moderate hemolysis

Order Code

IGF1

EPIC (Premier) Code

LAB369

Includes

N/A

CPT Code

  • 84305

Billing Code

  • 670089

CPT Statement

CPT Statement

Methodology

Liquid Chromatography/Mass Spectrometry (LC/MS)

FDA Status

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Physician Attestation of Informed Consent

N/A

Testing Laboratory

Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675

Department

Reference Testing

Reference Range

 Pediatric Male (ng/mL) Female (ng/mL)
<1 Years 14-142 17-185
1-1.9 Years 12-134 15-175
2-2.9 Years 12-135 16-179
3-3.9 Years 30-155 38-214
4-4.9 Years 28-181 34-238
5-5.9 Years 31-214 37-272
6-6.9 Years 38-253 45-316
7-7.9 Years 48-298 58-367
8-8.9 Years 62-347 76-424
9-9.9 Years 80-398 99-483
10-10.9 Years 100-449 125-541
11-11.9 Years 123-497 152-593
12-12.9 Years 146-541 178-636
13-13.9 Years 168-576 200-664
14-14.9 Years 187-599 214-673
15-15.9 Years 201-609 218-659
16-16.9 Years 209-602 208-619
17-17.9 Years 207-576 185-551

Adult (ng/mL)
18-19.9 Years 108-548
20-24.9 Years 83-456
25-29.9 Years 63-373
30-39.9 Years 53-331
40-49.9 Years 52-328
50-59.9 Years 50-317
60-69.9 Years 41-279
70-79.9 Years 34-245
>80 Years 34-246

Z-Score (Male) -2.0 - +2.0 SD
Z-Score (Female) -2.0 - +2.0 SD

Pediatric Tanner Stages See Laboratory Report

Setup Schedule / Expected Turnaround Time

Daily; Report available: 1 - 4 days

Specimen Collection

Special Instructions

N/A

Preferred Specimen

0.5 mL serum

Minimum Volume

0.3 mL

Instructions

Collect blood in a red-top or SST vacutainer. For red-top vacutainers, allow blood to clot (10-15 minutes) at room temperature. Separate serum from cells and refrigerate.

Patient Preparation

N/A

Storage

Plastic screw-cap vial

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

  • Room temperature: 48 hours
  • Refrigerated: 7 days
  • Frozen: 60 days

Limitations

N/A

Other Acceptable Specimens

N/A

Unacceptable Specimens

Moderate hemolysis

Billing

CPT Code

  • 84305

Billing Code

  • 670089

CPT Statement

CPT Statement

Result Information

Methodology

Liquid Chromatography/Mass Spectrometry (LC/MS)

Testing Laboratory

N/A

Reference Range

 Pediatric Male (ng/mL) Female (ng/mL)
<1 Years 14-142 17-185
1-1.9 Years 12-134 15-175
2-2.9 Years 12-135 16-179
3-3.9 Years 30-155 38-214
4-4.9 Years 28-181 34-238
5-5.9 Years 31-214 37-272
6-6.9 Years 38-253 45-316
7-7.9 Years 48-298 58-367
8-8.9 Years 62-347 76-424
9-9.9 Years 80-398 99-483
10-10.9 Years 100-449 125-541
11-11.9 Years 123-497 152-593
12-12.9 Years 146-541 178-636
13-13.9 Years 168-576 200-664
14-14.9 Years 187-599 214-673
15-15.9 Years 201-609 218-659
16-16.9 Years 209-602 208-619
17-17.9 Years 207-576 185-551

Adult (ng/mL)
18-19.9 Years 108-548
20-24.9 Years 83-456
25-29.9 Years 63-373
30-39.9 Years 53-331
40-49.9 Years 52-328
50-59.9 Years 50-317
60-69.9 Years 41-279
70-79.9 Years 34-245
>80 Years 34-246

Z-Score (Male) -2.0 - +2.0 SD
Z-Score (Female) -2.0 - +2.0 SD

Pediatric Tanner Stages See Laboratory Report

Setup Schedule / Expected Turnaround Time

Daily; Report available: 1 - 4 days