Hu, Yo, and Ri Antibodies with Reflex to Titers and Western Blot, CSF
Test Summary
Hu anti-neuronal nuclear antibody (anti-Hu) is found in 5-10% of patients with small cell carcinoma of the lung. Purkinje cell (Yo) antibody is found in patients with paraneoplastic cerebellar degeneration and is associated with breast, ovarian, and other gynecologic cancers. Some patients with ovarian cancer have low titers of Yo antibodies in the absence of cerebellar degeneration. Anti-Hu antibodies are associated with paraneoplastic encephalomyelitis and sensory neuropathy. Anti-Ri antibody can be detected in patients with paraneoplastic opsoclonus/myoclonus syndrome. Neoplasms most often associated with anti-Ri include breast cancer, small cell lung cancer, and gynecological cancers.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
2.4 mL CSF
Minimum Volume
1.5 mL
Instructions
N/A
Patient Preparation
Overnight fasting is preferred
Storage
Sterile screw-cap vial
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: 8 hours
- Refrigerated: 7 days
- Frozen: 6 months
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
Received room temperature
Order Code
HUYORI
EPIC (Premier) Code
LAB5510
Includes
Hu Antibody Screen with Reflex to Titer and Western Blot, CSF
Yo Antibody Screen with Reflex to Titer and Western Blot, CSF
Ri Antibody Screen with Reflex to Titer and Western Blot, CSF
If Hu Antibody Screen, IFA, CSF is Positive, then Hu Antibody, WB, CSF will be performed at an additional charge (CPT code(s): 84181).
If Hu Antibody, WB, CSF is Positive, then Hu Antibody Titer, CSF will be performed at an additional charge (CPT code(s): 86256).
If Yo Antibody Screen, IFA, CSF is Positive, then Yo Antibody, WB, CSF will be performed at an additional charge (CPT code(s): 84181).
If Yo Antibody, WB, CSF is Positive, then Yo Antibody, Titer, CSF will be performed at an additional charge (CPT code(s): 86256).
If Ri Antibody Screen, IFA, CSF is Positive, then Ri Antibody, WB, CSF will be performed at an additional charge (CPT codes: 84181).
If Ri Antibody, WB, CSF is Positive, then Ri Antibody, Titer, CSF will be performed at an additional charge (CPT code(s): 86256).
Yo Antibody Screen with Reflex to Titer and Western Blot, CSF
Ri Antibody Screen with Reflex to Titer and Western Blot, CSF
If Hu Antibody Screen, IFA, CSF is Positive, then Hu Antibody, WB, CSF will be performed at an additional charge (CPT code(s): 84181).
If Hu Antibody, WB, CSF is Positive, then Hu Antibody Titer, CSF will be performed at an additional charge (CPT code(s): 86256).
If Yo Antibody Screen, IFA, CSF is Positive, then Yo Antibody, WB, CSF will be performed at an additional charge (CPT code(s): 84181).
If Yo Antibody, WB, CSF is Positive, then Yo Antibody, Titer, CSF will be performed at an additional charge (CPT code(s): 86256).
If Ri Antibody Screen, IFA, CSF is Positive, then Ri Antibody, WB, CSF will be performed at an additional charge (CPT codes: 84181).
If Ri Antibody, WB, CSF is Positive, then Ri Antibody, Titer, CSF will be performed at an additional charge (CPT code(s): 86256).
CPT Code
- 86255 (x3)
Billing Code
- 670074
CPT Statement
Methodology
Immunofluorescence Assay (IFA)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675
33608 Ortega Highway
San Juan Capistrano CA, 92675
Department
Reference Testing
Reference Range
N/A
Setup Schedule / Expected Turnaround Time
Monday, Wednesday, Friday morning; Report available: 4 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
2.4 mL CSF
Minimum Volume
1.5 mL
Instructions
N/A
Patient Preparation
Overnight fasting is preferred
Storage
Sterile screw-cap vial
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: 8 hours
- Refrigerated: 7 days
- Frozen: 6 months
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
Received room temperature
Result Information
Methodology
Immunofluorescence Assay (IFA)
Testing Laboratory
N/A
Reference Range
N/A
Setup Schedule / Expected Turnaround Time
Monday, Wednesday, Friday morning; Report available: 4 days