Hu Antibody Screen with Reflex to Titer and Western Blot, CSF
Test Summary
Paraneoplastic Syndrome involves non-metastatic systemic effects that accompany malignant disease. Antineuronal Nuclear Antibody (Anti-Hu) is found in 5-10% of patients with small cell carcinoma of the lung. Anti-Hu is associated with subacute syndrome of encephalomyeloradiculopathy, sensory neuropathy, and autoimmune neuropathy, predominantly affecting the gastrointestinal tract.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
3 mL CSF
Minimum Volume
1.5 mL
Instructions
N/A
Patient Preparation
Overnight fasting is preferred
Storage
Sterile screw-cap container
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: Unacceptable
- Refrigerated: 7 days
- Frozen: 6 months
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
Received room temperature
Order Code
HUCSF
EPIC (Premier) Code
LAB3906
Includes
If Hu Antibody Screen, IFA, CSF is positive, then Hu Antibody, WB, CSF will be performed at an additional charge (CPT code(s): 84181).
If Hu Antibody, WB, CSF is positive, then Hu Antibody Titer, CSF will be performed at an additional charge (CPT code(s): 86256).
If Hu Antibody, WB, CSF is positive, then Hu Antibody Titer, CSF will be performed at an additional charge (CPT code(s): 86256).
CPT Code
- 86255
Billing Code
- 670072
CPT Statement
Methodology
Immunofluorescence Assay (IFA) • Western Blot (WB)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675
33608 Ortega Highway
San Juan Capistrano CA, 92675
Department
Reference Testing
Reference Range
| Hu Ab Screen, IFA, CSF | Negative |
| Hu Ab, WB, CSF | Negative |
| Hu Ab Titer, CSF | No Hu Antibodies detected in undiluted CSF samples |
Setup Schedule / Expected Turnaround Time
Monday, Wednesday, Friday morning; Report available: 4 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
3 mL CSF
Minimum Volume
1.5 mL
Instructions
N/A
Patient Preparation
Overnight fasting is preferred
Storage
Sterile screw-cap container
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: Unacceptable
- Refrigerated: 7 days
- Frozen: 6 months
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
Received room temperature
Result Information
Methodology
Immunofluorescence Assay (IFA) • Western Blot (WB)
Testing Laboratory
N/A
Reference Range
| Hu Ab Screen, IFA, CSF | Negative |
| Hu Ab, WB, CSF | Negative |
| Hu Ab Titer, CSF | No Hu Antibodies detected in undiluted CSF samples |
Setup Schedule / Expected Turnaround Time
Monday, Wednesday, Friday morning; Report available: 4 days