Histamine Release (Chronic Urticaria)
Test Summary
Chronic Urticaria (CU) is a common skin disorder affecting 1 to 6% of the general population. It is characterized by repeated occurrence of short-lived cutaneous wheals accompanied by redness and itching. Autoimmune urticaria is defined by the presence of a functional IgG antibody to high-affinity IgE receptor (Fc epsilon RI alpha) or IgE. These antibodies trigger mast cell and basophil degranulation by the engagement of Fc epsilon receptor. Functional IgG antibody to the receptor has been identified in approximately 30-40% of patients with CU, and anti IgE antibody has been identified in another 5%-10%.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1.5 mL serum collected in a red-top tube (no gel)
Minimum Volume
1 mL
Instructions
N/A
Patient Preparation
Patients taking calcineurin inhibitors should stop their medication for 72 hours prior to draw
Storage
Plastic screw-cap vial
Transport Temperature
Room temperature
Specimen Stability
- Room temperature7 days
- Refrigerated: 7 days
- Frozen: 30 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
Gross hemolysis • Grossly lipemic • Icteric • Specimen other than serum • Serum separator tube (SST)
Order Code
HISTAM
EPIC (Premier) Code
LAB6041
Includes
N/A
CPT Code
- 86343
Billing Code
- 670045
CPT Statement
Methodology
Cell Culture (CC) • Immunoassay (IA)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675
33608 Ortega Highway
San Juan Capistrano CA, 92675
Department
Reference Testing
Reference Range
<16 %
Setup Schedule / Expected Turnaround Time
Tuesday, Thursday morning; Report available: 3 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1.5 mL serum collected in a red-top tube (no gel)
Minimum Volume
1 mL
Instructions
N/A
Patient Preparation
Patients taking calcineurin inhibitors should stop their medication for 72 hours prior to draw
Storage
Plastic screw-cap vial
Transport Temperature
Room temperature
Specimen Stability
- Room temperature7 days
- Refrigerated: 7 days
- Frozen: 30 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
Gross hemolysis • Grossly lipemic • Icteric • Specimen other than serum • Serum separator tube (SST)
Result Information
Methodology
Cell Culture (CC) • Immunoassay (IA)
Testing Laboratory
N/A
Reference Range
<16 %
Setup Schedule / Expected Turnaround Time
Tuesday, Thursday morning; Report available: 3 days