HE4, Ovarian Cancer Monitoring
Test Summary
The percentage increase in HE4 values has been used as an aid in monitoring recurrence or progressive disease in patients with invasive epithelial ovarian cancer. Currently there is no clinically accepted cut-off for use in monitoring cancer progression in epithelial ovarian cancer subjects with this assay. Serial testing for patient HE4 assay values should be used in conjunction with methods used for monitoring ovarian cancer.
Aliases
- Human Epididymis Protein 4
Specimen Collection
Special Instructions
Preferred Specimen
Minimum Volume
Instructions
Patient Preparation
Storage
Transport Temperature
Specimen Stability
- Room Temperature = 48 hours
- Refrigerated = 72 hours
- Frozen = 28 days
Limitations
A clinical study indicated that serial HE4 levels correlated with clinical status (progression vs. no progression) in 70% (247/354) of the study participants.
Other Acceptable Specimens
SST (speckled top) tube
Unacceptable Specimens
Order Code
EPIC (Premier) Code
Includes
CPT Code
- 86305
Billing Code
- 671006
CPT Statement
Methodology
FDA Status
Physician Attestation of Informed Consent
Testing Laboratory
33608 Ortega Highway
San Juan Capistrano CA, 92675
Department
Reference Range
| Female Premenopausal | ≤70 pmol/L |
| Female Postmenopausal | ≤140 pmol/L |
Setup Schedule / Expected Turnaround Time
Specimen Collection
Special Instructions
Preferred Specimen
Minimum Volume
Instructions
Patient Preparation
Storage
Transport Temperature
Specimen Stability
- Room Temperature = 48 hours
- Refrigerated = 72 hours
- Frozen = 28 days
Limitations
A clinical study indicated that serial HE4 levels correlated with clinical status (progression vs. no progression) in 70% (247/354) of the study participants.
Other Acceptable Specimens
SST (speckled top) tube
Unacceptable Specimens
Result Information
Methodology
Testing Laboratory
Reference Range
| Female Premenopausal | ≤70 pmol/L |
| Female Postmenopausal | ≤140 pmol/L |