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Test Directory

Test Directory Cytochrome P450 2D6 Genotype

Cytochrome P450 2D6 Genotype

Test Summary

The CYP2D6 gene product is responsible for the metabolism of many major drug groups including many antidepressants, neuroleptics, and cardiovascular drugs. Cytochrome 450 2D6 Genotype detects eight alleles associated with the poor metabolizer phenotype (PM). Patients with duplication of the CYP2D6 gene are ultra extensive metabolizers (UEM). Approximately 5-10% of Caucasian individuals express PM phenotype and the same percentage the UEM phenotype.

Aliases

Specimen Collection

Special Instructions

N/A

Preferred Specimen

5 mL EDTA whole blood collected in EDTA (lavender-top) tube, EDTA (royal blue-top) tube, ACD (yellow-top) tube, or sodium heparin (green-top) tube

Minimum Volume

3 mL

Instructions

Specimen stability is crucial. Store and ship at room temperature immediately. Do not freeze.

Extracted DNA: Please call 1-866-GENE-INFO (1-866-436-3463) for additional information.

Patient Preparation

N/A

Storage

Lavender top tube (EDTA) or (dark/royal blue-top) tube • ACD (yellow-top, Solution-A, -B) tube • Sodium heparin (green-top) tube • Plastic, screw-capped, aliquot tube or vial

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 8 days
Refrigerated: 8 days
Frozen: Unacceptable

Limitations

The metabolism of drugs is influenced by genotype and other factors.

Other Acceptable Specimens

5 mL bone marrow collected in EDTA (lavender-top) tube, EDTA (royal blue-top) tube, ACD (yellow-top) tube, or sodium heparin (green-top) tube

Unacceptable Specimens

N/A

Order Code

CYTOGT

EPIC (Premier) Code

LAB3052

Includes

N/A

CPT Code

81226

Billing Code

670849

CPT Statement

Methodology

Polymerase Chain Reaction (PCR) • Single Nucleotide Primer Extension Reaction (SNP-IT)

FDA Status

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Physician Attestation of Informed Consent

This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.

Testing Laboratory

Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675

Department

Reference Testing

Reference Range

See Laboratory Report

Setup Schedule / Expected Turnaround Time

Monday, Thursday; Report available: 7 days