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Test Directory » Cytochrome P450 2D6 Genotype

Cytochrome P450 2D6 Genotype

Order Code: CYTOGT

Test Summary

The CYP2D6 gene product is responsible for the metabolism of many major drug groups including many antidepressants, neuroleptics, and cardiovascular drugs. Cytochrome 450 2D6 Genotype detects eight alleles associated with the poor metabolizer phenotype (PM). Patients with duplication of the CYP2D6 gene are ultra extensive metabolizers (UEM). Approximately 5-10% of Caucasian individuals express PM phenotype and the same percentage the UEM phenotype.

Aliases

  • 2D6
  • CYP2D6
  • Tamoxifen Resistance

Specimen Collection

Special Instructions

N/A

Preferred Specimen

5 mL EDTA whole blood collected in EDTA (lavender-top) tube, EDTA (royal blue-top) tube, ACD (yellow-top) tube, or sodium heparin (green-top) tube

Minimum Volume

3 mL

Instructions

Specimen stability is crucial. Store and ship at room temperature immediately. Do not freeze.

Extracted DNA: Please call 1-866-GENE-INFO (1-866-436-3463) for additional information.

Patient Preparation

N/A

Storage

N/A

Transport Temperature

Room temperature

Specimen Stability

  • Room temperature: 8 days
  • Refrigerated: 8 days
  • Frozen: Unacceptable

Limitations

N/A

Other Acceptable Specimens

Bone marrow collected in: EDTA (lavender or royal blue-top), ACD solution (yellow-top), or sodium heparin (green-top) tube

Unacceptable Specimens

Wrong specimen type • Received Frozen • Exceeds specimen stability • Quantity not sufficient (QNS)

Order Code

CYTOGT

EPIC (Premier) Code

LAB3052

Includes

N/A

CPT Code

  • 81226

Billing Code

  • 670849

CPT Statement

CPT Statement

Methodology

Polymerase Chain Reaction (PCR) • Single Nucleotide Primer Extension Reaction (SNP-IT)

FDA Status

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Physician Attestation of Informed Consent

N/A

Testing Laboratory

Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675

Department

Reference Testing

Reference Range

See Laboratory Report

Setup Schedule / Expected Turnaround Time

Monday, Thursday; Report available: 5 - 6 days

Specimen Collection

Special Instructions

N/A

Preferred Specimen

5 mL EDTA whole blood collected in EDTA (lavender-top) tube, EDTA (royal blue-top) tube, ACD (yellow-top) tube, or sodium heparin (green-top) tube

Minimum Volume

3 mL

Instructions

Specimen stability is crucial. Store and ship at room temperature immediately. Do not freeze.

Extracted DNA: Please call 1-866-GENE-INFO (1-866-436-3463) for additional information.

Patient Preparation

N/A

Storage

N/A

Transport Temperature

Room temperature

Specimen Stability

  • Room temperature: 8 days
  • Refrigerated: 8 days
  • Frozen: Unacceptable

Limitations

N/A

Other Acceptable Specimens

Bone marrow collected in: EDTA (lavender or royal blue-top), ACD solution (yellow-top), or sodium heparin (green-top) tube

Unacceptable Specimens

Wrong specimen type • Received Frozen • Exceeds specimen stability • Quantity not sufficient (QNS)

Billing

CPT Code

  • 81226

Billing Code

  • 670849

CPT Statement

CPT Statement

Result Information

Methodology

Polymerase Chain Reaction (PCR) • Single Nucleotide Primer Extension Reaction (SNP-IT)

Testing Laboratory

N/A

Reference Range

See Laboratory Report

Setup Schedule / Expected Turnaround Time

Monday, Thursday; Report available: 5 - 6 days