Cortisol, Free, 24-Hour Urine with Creatinine, LC/MS/MS
Test Summary
Urinary Free Cortisol is useful in the detection of patients with Cushing's syndrome for whom Free Cortisol concentrations are elevated.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
2 mL of a 24-hour urine collected in a leak-proof urine container, no preservative
Minimum Volume
0.5 mL
Instructions
Record 24-hour urine volume on test requisition and urine vial. Reference ranges do not apply to random urine samples.
Patient Preparation
N/A
Storage
Urine Container, leak-proof
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: 14 days
- Refrigerated: 21 days
- Frozen: 90 days
Limitations
N/A
Other Acceptable Specimens
24-hour urine in 25 mL 6N HCl, or 10 mL concentrated glacial acetic acid, or in 10 grams boric acid, submitted in a leak-proof urine container
Unacceptable Specimens
N/A
Order Code
CORTFU
EPIC (Premier) Code
LAB125
Includes
CPT code 81050 may be added at an additional charge for volume measurement
CPT Code
- 82530
Billing Code
- 670868
CPT Statement
Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675
33608 Ortega Highway
San Juan Capistrano CA, 92675
Department
Reference Testing
Reference Range
Cortisol, Free, 24-Hr Urine
Creatinine, 24-Hour Urine
| Adult | 4.0-50.0 |
| Pediatric | |
| 1-4 Years | 0.9-8.2 mcg/24 hrs |
| 5-9 Years | 1.0-30.0 mcg/24 hrs |
| 10-13 Years | 1.0-45.0 mcg/24 hrs |
| 14-17 Years | 3.0-55.0 mcg/24 hrs |
Creatinine, 24-Hour Urine
| <3 Years | Not established | |
| 3-8 Years | 0.10-0.80 g/24 hours | |
| 9-12 Years | 0.20-1.40 g/24 hours | |
| 13-17 Years | 0.40-1.90 g/24 hours | |
| >17 Years | 0.50-2.15 g/24 hours | |
Setup Schedule / Expected Turnaround Time
Monday - Friday evening; Report available: 3 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
2 mL of a 24-hour urine collected in a leak-proof urine container, no preservative
Minimum Volume
0.5 mL
Instructions
Record 24-hour urine volume on test requisition and urine vial. Reference ranges do not apply to random urine samples.
Patient Preparation
N/A
Storage
Urine Container, leak-proof
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: 14 days
- Refrigerated: 21 days
- Frozen: 90 days
Limitations
N/A
Other Acceptable Specimens
24-hour urine in 25 mL 6N HCl, or 10 mL concentrated glacial acetic acid, or in 10 grams boric acid, submitted in a leak-proof urine container
Unacceptable Specimens
N/A
Result Information
Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Testing Laboratory
N/A
Reference Range
Cortisol, Free, 24-Hr Urine
Creatinine, 24-Hour Urine
| Adult | 4.0-50.0 |
| Pediatric | |
| 1-4 Years | 0.9-8.2 mcg/24 hrs |
| 5-9 Years | 1.0-30.0 mcg/24 hrs |
| 10-13 Years | 1.0-45.0 mcg/24 hrs |
| 14-17 Years | 3.0-55.0 mcg/24 hrs |
Creatinine, 24-Hour Urine
| <3 Years | Not established | |
| 3-8 Years | 0.10-0.80 g/24 hours | |
| 9-12 Years | 0.20-1.40 g/24 hours | |
| 13-17 Years | 0.40-1.90 g/24 hours | |
| >17 Years | 0.50-2.15 g/24 hours | |
Setup Schedule / Expected Turnaround Time
Monday - Friday evening; Report available: 3 days