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Test Directory Chromosome Analysis and Alpha-Fetoprotein with/Reflex to AchE and Fetal Hgb, Amniotic Fluid

Chromosome Analysis and Alpha-Fetoprotein with/Reflex to AchE and Fetal Hgb, Amniotic Fluid

Test Summary

This test will detect chromosome abnormalities of the fetus including numerical, structural, and mosaic abnormalities. Chromosome analysis will also reveal fetal sex and sex chromosome abnormalities. Indications for prenatal chromosome analysis may include advanced maternal age, abnormal fetal ultrasound, abnormal maternal serum screen, abnormal cell-free DNA results, history of a previous child with a chromosome abnormality, or a parent who carries a balanced chromosomal rearrangement or has another chromosome abnormality.

Aliases

Specimen Collection

Special Instructions

N/A

Preferred Specimen

20 mL amniotic fluid collected in a sterile screw-cap container

Minimum Volume

5 mL

Instructions

30 mL is preferred if other testing, e.g. microarray, FISH is ordered.

Ship at room temperature. Do not freeze.
Send all tubes to lab (supernatant for AFP will be split by cytogenetics lab).

Please contact the laboratory Genetic Counselor at 1-866-GENEINFO (1-866-436-3463) with any questions.

Patient Preparation

N/A

Storage

N/A

Transport Temperature

Room temperature

Specimen Stability

Room temperature: Preferred
Refrigerated: Acceptable
Frozen: Unacceptable

Limitations

N/A

Other Acceptable Specimens

N/A

Unacceptable Specimens

Received frozen

Order Code

CHRMFL

EPIC (Premier) Code

N/A

Includes

If the amniotic fluid AFP MoM is ≥2.0, then Acetylcholinesterase and Fetal Hemoglobin by ID will be performed at an additional charge (CPT code(s): 82664, 83033).

CPT Code

82106
88235
88267
88280

Billing Code

670956
670957
670958
670952

CPT Statement

Methodology

Culture • Karyotype • Microscopy

AFP: Immunoassay (IA) • Gel Electrophoresis • Immunodiffusion (ID)

FDA Status

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Physician Attestation of Informed Consent

This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.

Testing Laboratory

Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675

Department

Reference Testing

Reference Range

See Laboratory Report

Setup Schedule / Expected Turnaround Time

Daily; Report available: 9 - 12 days, additional days for reflex if needed