Follicular Lymphoma, BCL-2/JH t(14;18), Real-Time PCR, Cell-based
Order Code:
BCL2JH
Test Summary
Follicular lymphoma is the most common type of non-Hodgkin's lymphoma in the United States. Up to 90% of follicular lymphomas carry BCL-2/JH t(14;18) (q32;Q21) chromosome translocation. The presence of the BCL-2 translocation has been associated with poor prognosis in one group of diffuse large-cell and follicular lymphoma patients. Analysis of BCL-2 translocations provides an important marker for detection and monitoring of malignancy during patient treatment and follow up.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
5 mL whole blood or bone marrow collected in an EDTA (lavender-top) tube
Minimum Volume
1 mL
Instructions
Fresh frozen tissue (acceptable): stable for approximately 1 year at -70ºC.
Fresh (unfixed) tissue in RPMI or tissue in formalin fixative (acceptable): Ship at room temperature or refrigerated. Identify what fixative or medium is used and write it on the sample container.
Fresh (unfixed) tissue in RPMI or tissue in formalin fixative (acceptable): Ship at room temperature or refrigerated. Identify what fixative or medium is used and write it on the sample container.
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Room temperature
Specimen Stability
- Whole blood and bone marrow
- Room temperature: 7 days
- Refrigerated: 14 days
- Frozen: Unacceptable
- Paraffin Block
- Room temperature: Indefinitely
- Refrigerated: Unacceptable
- Fro
Limitations
N/A
Other Acceptable Specimens
Formalin-fixed, paraffin-embedded tissue block • Fresh (unfixed) tissue submitted in RPMI or in formalin fixative
Unacceptable Specimens
N/A
Order Code
BCL2JH
EPIC (Premier) Code
LAB3206
Includes
N/A
CPT Code
- 81278 -
Billing Code
- 670861
CPT Statement
Methodology
Real-Time Polymerase Chain Reaction (RT-PCR)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675
33608 Ortega Highway
San Juan Capistrano CA, 92675
Department
Reference Testing
Reference Range
Negative
Setup Schedule / Expected Turnaround Time
Tuesday, Saturday; Report available: 4 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
5 mL whole blood or bone marrow collected in an EDTA (lavender-top) tube
Minimum Volume
1 mL
Instructions
Fresh frozen tissue (acceptable): stable for approximately 1 year at -70ºC.
Fresh (unfixed) tissue in RPMI or tissue in formalin fixative (acceptable): Ship at room temperature or refrigerated. Identify what fixative or medium is used and write it on the sample container.
Fresh (unfixed) tissue in RPMI or tissue in formalin fixative (acceptable): Ship at room temperature or refrigerated. Identify what fixative or medium is used and write it on the sample container.
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Room temperature
Specimen Stability
- Whole blood and bone marrow
- Room temperature: 7 days
- Refrigerated: 14 days
- Frozen: Unacceptable
- Paraffin Block
- Room temperature: Indefinitely
- Refrigerated: Unacceptable
- Fro
Limitations
N/A
Other Acceptable Specimens
Formalin-fixed, paraffin-embedded tissue block • Fresh (unfixed) tissue submitted in RPMI or in formalin fixative
Unacceptable Specimens
N/A
Result Information
Methodology
Real-Time Polymerase Chain Reaction (RT-PCR)
Testing Laboratory
N/A
Reference Range
Negative
Setup Schedule / Expected Turnaround Time
Tuesday, Saturday; Report available: 4 days