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Test Directory » Mantle Cell Lymphoma, bcl-1/JH, t(11;14), Cell-Based

Test Directory Mantle Cell Lymphoma, bcl-1/JH, t(11;14), Cell-Based

Mantle Cell Lymphoma, bcl-1/JH, t(11;14), Cell-Based

Order Code: BCL1JH

Test Summary

Bcl-1/JH t(11;14) is highly specific for mantle cell lymphoma (MCL). The t(11;14) can be found in approximately 70% to 95% cases of MCL. Half of these translocations fall within the BCL-1 major translocation cluster (MTC). The t(11;14) Real-Time PCR assay can be used to monitor minimal residual disease in NHL. Ideally, recent patient samples should be tested side by side with the previous sample to better illustrate the quantitative changes.

Aliases

bcl-1/JH t(11;14)

Specimen Collection

Special Instructions

N/A

Preferred Specimen

5 mL bone marrow collected in an EDTA (lavender-top) tube

Minimum Volume

1 mL

Instructions

Collect whole blood or bone marrow in an EDTA (lavender-top) tube ship refrigerated or room temperature. Stability of whole blood and bone marrow samples at room temperature is 1 week and at refrigerated temperature is 2 weeks. Paraffin blocks are to be shipped at room temperature. Stability for paraffin blocks is indefinite. For tissue samples, fresh frozen tissue is preferred and to be shipped frozen. Frozen tissue is stable for approximately 1 year at -70°C. Fresh (unfixed) must be in RPMI. Tissues in fromalin fixative or RPMI are to be shipped at room temperature or refrigerated. Identify what fixative or media is used and write it on the samples container.

Patient Preparation

N/A

Storage

N/A

Transport Temperature

Room temperature

Specimen Stability

Bone marrow and whole blood:
Room temperature: 7 days
Refrigerated: 14 days
Frozen: Unacceptable
Tissue block:
Room temperature: Indefinitely
Refrigerated: Unacceptable
Fro

Limitations

N/A

Other Acceptable Specimens

Whole blood collected in: EDTA (lavender-top) tube • Fresh (unfixed tissue) • Formalin-fixed, paraffin embedded tissue block • Tissue (biopsy)

Unacceptable Specimens

N/A

Order Code

BCL1JH

EPIC (Premier) Code

LAB3205

Includes

N/A

CPT Code

81168

Billing Code

670860

CPT Statement

Methodology

Real-Time Polymerase Chain Reaction (RT-PCR)

FDA Status

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Physician Attestation of Informed Consent

N/A

Testing Laboratory

Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675

Department

Reference Testing

Reference Range

0/Negative

Setup Schedule / Expected Turnaround Time

Tuesday, Saturday; Report available: 3 days