Advanced Lipid Panel, Cardio IQ®
Order Code: CARLIP
Test Summary
The advanced lipid profile provides a more comprehensive assessment of dyslipidemia and cardiovascular risk than standard lipid panel measurements. Standard lipid panels measure total cholesterol, HDL-C, and triglycerides, and a calculated LDL-C, but do not capture all of the complexity of dyslipidemia and associated CVD risk. For a substantial number of individuals, lipoprotein measures such as LDL particle number, ApoB and Lp(a) add to the predictive power of standard lipid assessment of CVD risk. The advanced lipid profile combines a standard lipid panel with 3 additional tests: lipoprotein subfraction assessment by ion mobility of LDL particle number and LDL and HDL particle subclass concentrations, the ApoB test, and the Lp(a) test.
Aliases
N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
3 mL serum AND 1 mL serum
Minimum Volume
1.75 mL AND 0.25 mL
Instructions
N/A
Patient Preparation
Fasting is not required prior to collection of a lipid panel. The assay manufacturer Beckman Coulter advises: "N-Acetyl Cysteine (NAC), when administered in therapeutic concentrations (for the treatment of acetaminophen overdose), has been. . . determined to interfere with assays for. . . cholesterol, uric acid" where "NAC interference may lead to falsely low results." According to Beckman Coulter, the NAC interference should be insignificant by 12 hours after completion of the initial loading dose of an IV infusion treatment regimen consisting of an initial loading dose of 150 mg/kg administered over 1 hour, a second dose of 50 mg/kg administered over 4 hrs and a third dose of 100 mg/kg administered over 16 hrs.
Storage
Plastic screw-cap vial
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: 24 hours
- Refrigerated: 7 days
- Frozen: 28 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
- Gross hemolysis
- Grossly lipemic
- Moderate to grossly icteric
Order Code
CARLIP
EPIC (Premier) Code
LAB5587
Includes
Cardio IQ® Cholesterol, Total
Cardio IQ® HDL Cholesterol
Cardio IQ® Triglycerides
Cardio IQ® Non-HDL and Calculated Components
Cardio IQ® Lipoprotein Fractionation, Ion Mobility
Cardio IQ® Apolipoprotein B
Cardio IQ® Lipoprotein (a)
If Triglyceride is >400 mg/dL, then Cardio IQ® Direct LDL will be performed at an additional charge (CPT code(s): 83721). If Triglyceride is extremely elevated, > 1293 mg/dL, this causes interference in the Cardio IQ® Direct LDL assay, therefore this test cannot be added.
Cardio IQ® HDL Cholesterol
Cardio IQ® Triglycerides
Cardio IQ® Non-HDL and Calculated Components
Cardio IQ® Lipoprotein Fractionation, Ion Mobility
Cardio IQ® Apolipoprotein B
Cardio IQ® Lipoprotein (a)
If Triglyceride is >400 mg/dL, then Cardio IQ® Direct LDL will be performed at an additional charge (CPT code(s): 83721). If Triglyceride is extremely elevated, > 1293 mg/dL, this causes interference in the Cardio IQ® Direct LDL assay, therefore this test cannot be added.
CPT Code
- 80061
- 83704. 82172
- 83695
Billing Code
- 671369
- 671370
- 671371
- 671372
CPT Statement
Methodology
Enzymatic • Spectrophotometric • Ion Mobility • Fixed Rate Nephelometry • Immunoturbidometric • Immunoassay (IA)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675
33608 Ortega Highway
San Juan Capistrano CA, 92675
Department
Reference Testing
Reference Range
See Laboratory Report
Setup Schedule / Expected Turnaround Time
Monday - Friday; Report available: 3 - 6 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
3 mL serum AND 1 mL serum
Minimum Volume
1.75 mL AND 0.25 mL
Instructions
N/A
Patient Preparation
Fasting is not required prior to collection of a lipid panel. The assay manufacturer Beckman Coulter advises: "N-Acetyl Cysteine (NAC), when administered in therapeutic concentrations (for the treatment of acetaminophen overdose), has been. . . determined to interfere with assays for. . . cholesterol, uric acid" where "NAC interference may lead to falsely low results." According to Beckman Coulter, the NAC interference should be insignificant by 12 hours after completion of the initial loading dose of an IV infusion treatment regimen consisting of an initial loading dose of 150 mg/kg administered over 1 hour, a second dose of 50 mg/kg administered over 4 hrs and a third dose of 100 mg/kg administered over 16 hrs.
Storage
Plastic screw-cap vial
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: 24 hours
- Refrigerated: 7 days
- Frozen: 28 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
- Gross hemolysis
- Grossly lipemic
- Moderate to grossly icteric
Billing
CPT Code
- 80061
- 83704. 82172
- 83695
Billing Code
- 671369
- 671370
- 671371
- 671372
CPT Statement
Result Information
Methodology
Enzymatic • Spectrophotometric • Ion Mobility • Fixed Rate Nephelometry • Immunoturbidometric • Immunoassay (IA)
Testing Laboratory
N/A
Reference Range
See Laboratory Report
Setup Schedule / Expected Turnaround Time
Monday - Friday; Report available: 3 - 6 days