Acetylcholine Receptor Binding Antibody
Order Code: ACETR
Test Summary
Myasthenia Gravis (MG) is an autoimmune neuromuscular disorder characterized by muscle weakness, most commonly due to autoantibody-mediated loss of functional acetylcholine receptors (AChR) in the neuromuscular junction. AChR binding autoantibodies are diagnostic of MG, and are found in 85-90% of MG patients. This assay aids in the differential diagnosis of conditions with MG-like muscle weakness and in monitoring therapeutic response. If binding antibodies are negative, assays for modulating and blocking antibodies should be considered.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Instructions
N/A
Patient Preparation
N/A
Storage
Plastic screw-cap vial
Transport Temperature
Refrigerated
Specimen Stability
- Room temperature: 14 days
- Refrigerated: 14 days
- Frozen: 30 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
Microbially contaminated • Gross hemolysis • Grossly lipemic
Order Code
ACETR
EPIC (Premier) Code
LAB008
Includes
N/A
CPT Code
- 86041
Billing Code
- 670516
CPT Statement
Methodology
Radioimmunoassay (RIA)
FDA Status
FDA Approved
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675
33608 Ortega Highway
San Juan Capistrano CA, 92675
Department
Reference Testing
Reference Range
| Negative | ≤0.30 nmol/L | |
| Equivocal | 0.31-0.49 nmol/L | |
| Positive | ≥0.50 nmol/L | |
Setup Schedule / Expected Turnaround Time
Tuesday - Saturday; Report available: 2 - 3 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Instructions
N/A
Patient Preparation
N/A
Storage
Plastic screw-cap vial
Transport Temperature
Refrigerated
Specimen Stability
- Room temperature: 14 days
- Refrigerated: 14 days
- Frozen: 30 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
Microbially contaminated • Gross hemolysis • Grossly lipemic
Result Information
Methodology
Radioimmunoassay (RIA)
Testing Laboratory
N/A
Reference Range
| Negative | ≤0.30 nmol/L | |
| Equivocal | 0.31-0.49 nmol/L | |
| Positive | ≥0.50 nmol/L | |
Setup Schedule / Expected Turnaround Time
Tuesday - Saturday; Report available: 2 - 3 days