Acetylcholine Receptor Modulating Antibody
Test Summary
Myasthenia Gravis (MG) is an autoimmune neuromuscular disorder characterized by muscle weakness, most commonly due to autoantibody-mediated loss of functional acetylcholine receptors (AChR) in the neuromuscular junction. AChR binding autoantibodies are diagnostic of MG, and are found in 85-90% of MG patients. AChR modulating antibodies cross-link AChR molecules on cell surface, promoting internalization, and decreasing AChR surface density. The AChR binding and modulating antibody assays have similar sensitivities, but performing them together increases sensitivity of antibody detection by approximately 5%.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Instructions
N/A
Patient Preparation
N/A
Storage
Transport tube
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 14 days
- Refrigerated: 14 days
- Frozen: 30 days
Limitations
Antibodies may not be found in congenital myasthenia.
Other Acceptable Specimens
N/A
Unacceptable Specimens
Gross hemolysis • Grossly lipemic • Microbially contaminated
Order Code
ACEMOD
EPIC (Premier) Code
LAB3116
Includes
N/A
CPT Code
- 86043
Billing Code
- 670515
CPT Statement
Methodology
Radiobinding Assay (RBA)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675
33608 Ortega Highway
San Juan Capistrano CA, 92675
Department
Reference Testing
Reference Range
<32 % Inhibition
Setup Schedule / Expected Turnaround Time
Sunday, Tuesday, Thursday; Report available: 3 - 8 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Instructions
N/A
Patient Preparation
N/A
Storage
Transport tube
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 14 days
- Refrigerated: 14 days
- Frozen: 30 days
Limitations
Antibodies may not be found in congenital myasthenia.
Other Acceptable Specimens
N/A
Unacceptable Specimens
Gross hemolysis • Grossly lipemic • Microbially contaminated
Result Information
Methodology
Radiobinding Assay (RBA)
Testing Laboratory
N/A
Reference Range
<32 % Inhibition
Setup Schedule / Expected Turnaround Time
Sunday, Tuesday, Thursday; Report available: 3 - 8 days