Oxycodone and Metabolite, Quantitative, Serum
Test Summary
For therapeutic drug monitoring of oxycodone (Oxycontin®, Percocet®, Percodan®). Oxycodone is a semisynthetic opioid analgesic. Steady state concentration is reached in 24-36 hours after initiation of therapy. Elimination half-life of oxycodone is 4.5 hours for controlled release and 3.2 hours for immediate release formulations. Peak plasma concentration of oxycodone is 11, 21, 39, 99, or 156 ng/mL after a single oral dose of 10, 20, 40, 80, or 160 mg respectively. Oxymorphone is a minor but active metabolite of oxycodone that is present at lower concentration in the circulation. Therapeutic concentrations for oxymorphone have not been established.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
5 mL serum collected in a red-top tube (no gel)
Minimum Volume
3 mL
Instructions
Do not use serum separator tubes.
Patient Preparation
N/A
Storage
Plastic screw-cap vial
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 7 days
- Refrigerated: 7 days
- Frozen: 7 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
N/A
Order Code
OXMETV
EPIC (Premier) Code
LAB5290
Includes
Oxycodone and Oxymorphone
CPT Code
- 80299
Billing Code
- 670380
CPT Statement
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute Valencia
27027 Tourney Road
Valencia CA, 91355
27027 Tourney Road
Valencia CA, 91355
Department
Reference Testing
Reference Range
| Oxycodone | 10-100 ng/mL |
Peak plasma concentrations 1 hour after a single immediate-release tablet containing 5 mg of Oxycodone: 9-38 ng/mL.
Peak plasma concentrations within 2.5 hours after 10 mg of immediate-release preparation of Oxycodone: 13-46 ng/mL.
Mean peak plasma concentrations following a single dose of a 40 to 80 mg controlled-release Oxycodone preparation: 39-100 ng/mL.
Toxicity may be significant at greater than 200 ng/mL.
However, concentrations associated with toxicity are variable and depend on an individual's tolerance to the drug.
Setup Schedule / Expected Turnaround Time
Monday, Wednesday, Friday; Report available: 3 - 5 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
5 mL serum collected in a red-top tube (no gel)
Minimum Volume
3 mL
Instructions
Do not use serum separator tubes.
Patient Preparation
N/A
Storage
Plastic screw-cap vial
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 7 days
- Refrigerated: 7 days
- Frozen: 7 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
N/A
Result Information
Methodology
Chromatography/Mass Spectrometry
Testing Laboratory
N/A
Reference Range
| Oxycodone | 10-100 ng/mL |
Peak plasma concentrations 1 hour after a single immediate-release tablet containing 5 mg of Oxycodone: 9-38 ng/mL.
Peak plasma concentrations within 2.5 hours after 10 mg of immediate-release preparation of Oxycodone: 13-46 ng/mL.
Mean peak plasma concentrations following a single dose of a 40 to 80 mg controlled-release Oxycodone preparation: 39-100 ng/mL.
Toxicity may be significant at greater than 200 ng/mL.
However, concentrations associated with toxicity are variable and depend on an individual's tolerance to the drug.
Setup Schedule / Expected Turnaround Time
Monday, Wednesday, Friday; Report available: 3 - 5 days